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Florence-Pisa-Rome and Rail and Drive Passes

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My family and I are going to Italy for 2 weeks. Within those days, I am staying in Florence for 4 days. Do you think we can go from Florence to Pisa (stay for a couple of hours) and straight to Rome on the same day? Or would that be crazy?

If it's doable, what would I do with our luggages? Is there a place to store your things at the station in Pisa? Should I take the eurail back to Rome, or the eurostar?

Also, we would be staying in Venice, Florence and Rome (flying in one city, out the other). I will travel via train to those main cities. Should I purchase a 3 day train pass or is it better to purchase point to point?

I was also reading a little about the rail and drive pass. What's your opinions or tips on this pass? When in Florence, I would like to rent a car one day to explore the Tuscany area. Other option I was told was to hire a driver.

Now, I am thinking I won't get to see much of Florence in 4 days if planning on seeing Pisa and Tuscany. Should I skip Pisa? I love the countryside. Any recommendations for a day trip here?

I was planning on traveling to Rome either on Saturday (the day before Easter), or on Easter Sunday. What's Rome like on those days? My husband wants to go to a mass on Sunday, but I heard it's crazy crowded and won't enjoy it.

And lastly, is Assisi and Orvieto ok to see in a day trip? I've seen tours for both those places in a day trip but not sure if it's too rushed.

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