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First time in Italy

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My husband and I are planning our first trip together to Italy sometime in mid-April for just one week. I'm in-charge of the itinerary. Here are the places we want to see:

1. Amalfi Coast (Positano)
2. Rome
3. Assisi
4. Republic of San Marino
5. Venice

We are flexible flying in to Naples or Rome and flying out of Venice and vice versa to cover more places and save time but then the concern about car rental comes in. Will it cost us a fortune to rent a car in Rome and return it in Venice? I'm also aware that driving around cities is a pain. I've done lots of reading and I'm still lost about the transportation part. I will be very thankful for all your suggestions!

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