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Driving route, Fiumicino to Siena

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Hi all,

I’ll be driving from the Rome airport to Siena, leaving in the early afternoon. I’ve looked at several maps and books, and it seems to me that you could take a route that is closer to the coast, or onw further inland, depending on which side of Rome you go around. Does anyone know if the driving times vary, and/or what the difference/appeal is of one route vs. the other?

Thanks!

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