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Carry on for 10 day trip?

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I know this has been covered ad nauseum (or however you spell it) but after schlepping an overweight (52 pounds) 25 inch suitcase to San Francisco for spring break, I decided I need to buck up and pack lighter for the trip to Italy in June. I want to do a carry-on and I need to go buy one. Is the 21 inch the largest I can get? We will be flying major airlines althought the Zurich to Venice leg may be a smaller plane. I went looking at 19 and 21 inchers and I am completely stumped as to how I will fit everything for 10 days in this thing!!!

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