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Bus from Munich to Prague

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My husband and I will be traveling from Garmisch, Germany, to Prague later this summer. Some of the routes I've seen on the RailEurope site include the bus from Munich to Prague. I've never taken the bus in Europe -- can anyone tell me what it's like? Do you prefer the train, or is there little difference, as the RailEurope site says?

Thanks in advance.

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