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bus from Istanbul - Ephesus: where to stop mid way

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2 women in early 60's in Turkey in August. We plan to take the bus from Istanbul to Ephesus/Selcuk,. 10 hours on the bus is too much for us and we have time for an overnight stop somewhere on the way. Any suggestions ? We like history, culture, nature, local foods and crafts, walking. We prefer bus, boat or train to plane or rental car. Not ritzy but comfortable is good. In good health and physically able.

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