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Best way to get from San Sebastian Spain to Puglia Italy

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We are attending a wedding next year in San Sebastian (from San Francisco) and from there want to travel to Italy for a few weeks, and we'd like to go to Puglia.

It's looking a little difficult to get there... Does anyone have any recommendations on budget airlines and which airlines to fly in and out of? There are not many options going from Santander or Bilbao, and getting to Madrid is 5 hours away. Even then, I'm not seeing very direct flights to Brindisi or Pescara.

Any suggestions are appreciated!

Thank you.

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