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Best way to Avignon from U.S.

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We are joining an excursion through France and Italy which starts in Avignon. What is the best way to get to Avignon from the U.S. (Las Vegas)? We have FF points on both Delta and American and I can transfer Marriott points over also. Less transfers/change planes is preferred. We won't need a car.
It's been fun reading different threads on here, which have been very helpful, but I couldn't find one that addressed this itinerary specifically. (Feel free to point me to another thread if there is one that answers this question.)
Thanks!

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