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Best train/car combination to get from Rome to Siena

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As part of our upcoming trip, we are checking out of our hotel in Rome on September 25th and heading to a hotel near Siena, where we will spend 5 nights. We will be renting a car that day and returning it in Florence before we fly back to Paris.

Our plan right now is to grab a train from Rome Termini, head north ("somewhere" - that's really the focus of my post), grab the car and then take a leisurely drive to Siena. I'd like to ensure that the journey to our hotel near Siena is as enjoyable and scenic as it can be - I can't wait for that part of the trip, actually.

I like train travel (though VERY rarely do so). So, I am happy to spend more money or time on the train if it means a beautiful, scenic trip. So, that's one option I need to figure out. Then again, I don't mind the idea of a faster train either :)

Another decision is where we are headed on the train. The ease of picking up the car is one factor but I'd also like to have a beautiful drive from wherever we get off the train to Siena. Again, we will be in no hurry. Orvieto and Chiusi have been mentioned. What about coastal destinations - anything that springs to mind?

Logistically, it seems I need to consider when the train arrives at our drop off point (time of day, so the car place is open), the fact that we are doing a one-way rental (a quick scan on AutoEurope suggested I could be restricted in terms of the pick up location, for one way rentals) and so on. We are traveling with one bag each so our luggage isn't a significant factor.

Anyway, there's all that expanse of Tuscany to the north of Rome :) We have plenty of time that day and I want to make the most of it. Would love to hear suggestions.

Thanks.

Mark

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