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Best 2 week itinerary for Madrid, Barcelona, Andalucia

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We are flying in round-trip to Madrid from San francisco mid-April for 2 weeks, and have yet to plan an itinerary. Any advice appreciated! I went to Spain 20+ years ago but this is the first time for my companion. We are both "veggie plus fish", and I've been reading the food advice with great interest, and how difficult it is to avoid meat..

This is what we are considering....

--2 days in Madrid leave by train for 3rd day for Andalucia. Is this practical?

--5 days in Granada, Seville, and one or two other places. We dont speak Spanish can we do this on our own or should we take a tour?

--5 days in Barcelona, get there from Andalucia by train

--Return to Madrid for last night

I've heard that it is better to fix itinerary and buy tickets early. Is it too ambitious to include Barcelona, Madrid and Andalusia in the same trip?

If there was one guidebook to take along, which would it be?

Also, with regard to hotels we prefer basic clean centrally located, I've heard they can be quite reasonable.

Thanks in advance!

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