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Barcelona to Salamanca: bus or train?

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We will be in Barcelona late next month and will need to get to Salamanca. The RENFE site shows one train daily, leaving 14.10 and arriving 22.51. I'm told the bus is faster and cheaper, but less comfortable. Does anyone have advice to offer about how much faster and cheaper, how to find schedules, whether it's best to buy tickets online in advance, etc.? Thanks for any help.

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