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7 days: Rome 2, Sienna 1, Florence 2, Cinque Terre 2

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Looking for advice on itinerary and trains to/from Cinque Terre. My wife and I (late 40s, good health, like walking) have a week in Italy in May. We have to fly in/out of Rome early on Monday to Monday. Current plans are Rome Mon/Tues night, train to Sienna for Wed night, train to Florence for Thurs night, then train to Cinque Terre late Friday for the weekend there, then late train back to Rome sunday night.

Doable or should we skip Sienna?
How long for train from Florence to CT?
How long does it take to get from CT back to Rome via train?
Recommendation for CT - which city to stay and hotel? We love the sea.
Thanks in advance, I've just read several threads on CT and lots of good advice on this forum.

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