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17 Days Route from Amsterdam to Zurich

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My wife and I are planning our first Europe trip in May next year (1 May - 17 May) . We will fly to Amsterdam and fly home from Zurich so our starting and ending points are fixed.
Now comes to our route from Amsterdam to Zurich.

There are so many places we are interested to go along the way but yeah we can't do all in the short 17D16N trip.
Looking at all the interesting places, we sort out 3 different routes that we "think" more geographically making sense. In the bracket is the number of nights we plan to stay.

Route 1: Amsterdam (3)- Rhine (3) - Dresden (2) - Prague (3) - Lugano or Lake Como (2) [Flight: Prague-Milan]- Lucerne (3)
Route 2: Amsterdam (3)- Berlin (2)- Prague (3)- Nuremburg (2)- Stuttgart (3)- Lucerne (3)
Route 3: Amsterdam (3) - Brussel (2)- Paris + countryside (5)- Stuttgart or Rhine (3)- Lucerne (3)

I wish to hear from you who had been to any of these which route do you think is the best. Or you have better opinion? And given our travel period at early to mid of May, which route/region is more pleasant to go?

Some background of us... 30 year old couple from South East Asia (that's why every places in Europe looked so different and interesting to us).
We like landscape, scenery, culture, buildings and food. We wish to include some variety in this trip instead of staying only at 2-3 places with similar atmosphere/scenery.
We particularly wish to go Prague and medieval old towns/villages but we could also save any of it in next trip (although I don't know when...)
We plan to use discounted train tickets so hope to finalize the route earlier to purchase tickets in advanced.

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