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10 Day South of France and Florence Trip?

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My friend and I are 22 year old females from NYC planning a trip to the South of France and Italy this summer. My friend is a nervous traveler with allergies, so we would like to stay in safe, clean places with easily accessible pharmacies and hospitals to make her feel more comfortable - but we are on a budget. We would love some suggestions for places that are rich with art and culture and can provide us with a balance of sight-seeing and relaxation.
We're thinking:

NYC-->Aeroport International Nice-Cote d'Azur
Nights 1-4: Probably Nice, Marseilles, Arles or Avignon
Day 5: Train to Florence with stop in Cinqe Terre or Genoa
Nights 5-9: Florence, maybe with day trip to Pisa or nearby towns

Where should we stay and where is worth visiting in the South of France?? Will we be able to travel from place to place via train easily? How long is needed in each place?


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